valsartan
Valsartan is an angiotensin II receptor antagonist in the class of antihypertensive drugs, which can block the type I (AT1) receptor of angiotensin II, increase the plasma level of angiotensin II, stimulate the unblocked AT2 receptor, and at the same time counteract the effect of AT1 receptor, so as to achieve the effect of dilating blood vessels and reducing blood pressure. In the United States, valsartan is used to treat high blood pressure, congestive heart failure, and post-myocardial infarction. Diovan Valsartan, developed and produced by Ciba-Jiagi, Switzerland, obtained the relevant patent rights in the United States and Europe in 1995 and 1996 respectively, and was listed in Germany for the first time in July 1996, and has since been listed in Europe, the United States and Japan. Ciba Giaggi and Sandoz merged to form Novartis in 1996. Valsartan has the characteristics of lasting and stable effect of lowering blood pressure and little side effects
Basic information
Chinese name: Valsartan
Chinese alias: Ambroxol hydrochloride impurity D; N-valoyl-n -[[2'-(1h-tetrazole-5-yl)[1,1' -biphenyl] -4-yl] methyl] -L-valine; Diovan; Valprosartan; Pulse xin
English name: valsartan
English alias: Valsartane; Tareg; Valsartan API; Valsratan; N-Valeryl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-L-valine; Diovan
CAS number: 137862-53-4
Molecular formula: C24H29N5O3
Structural formula:
Molecular weight: 435.51900
Accurate mass: 435.22700
PSA: 112.07000
LogP: 4.16170 [1]
Physicochemical property
Appearance and properties: This product is white crystal or white, white powder; It is hygroscopic. It is highly soluble in ethanol, easily soluble in methanol, slightly soluble in ethyl acetate, and almost insoluble in water.
Density: 1.212g/cm3
Melting point: 116-117°C
Boiling point: 684.9ºC at 760 mmHg
Flash point: 368ºC
Refractive index: 1.586
Storage condition: Keep in a cool place away from light
Vapor pressure: 1.06E-19mmHg at 25°C
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