Product Description
Pharmacological effect:
Thiamine is a fat-soluble derivative of thiamine and has higher bioavailability than thiamine. However, thiamine must be dephosphorylated by alkaline phosphatase to become a fat-soluble precursor before it can cross the cell membrane to play its biological effect. It is mainly used for the treatment of diabetic complications, especially for the treatment and prevention of diabetic retinopathy with Chemicalbook. Compared with other thiamine derivatives, this product is absorbed more rapidly and completely after oral administration. After absorption into the systemic circulation, phenylphosphothiamine is rapidly metabolized into thiamine without increasing the concentration of the drug in the brain. Meanwhile, equine uric acid is produced and excreted in the urine.
Biological activity:
Benfotiamine (S-Benzoylthiamine O-monophosphate) is a fat-soluble analogue of vitamin B1, which has higher absorptivity and bioavailability than vitamin B1 and is commonly used as a food supplement for complications of diabetes. Benfotiamine has direct antioxidant properties that prevent DNA damage
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