Benfotiamine

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Product Description

Benfotiamine Biological Activity

Description

Benfotiamine is a synthetic S-acyl derivative of thiamine (vitamin B1); an antioxidant dietary supplement.IC50 value:Target: Benfotiamine, the lipid-soluble thiamine derivative used as a treatment for diabetic neuropathy, can inhibit three major pathways(the hexosamine pathway, the advanced glycation end product (AGE) formation pathway and the diacylglycerol (DAG)?protein kinase C (PKC) pathway)of hyperglycemic damage and prevent experimental diabetic retinopathy. Benfotiamine is a synthetic S-acyl derivative of thiamine (vitamin B1) for treating sciatica and other painful nerve conditions. More effective at increasing thiamin levels in blood and tissues than water-soluble salts like the previous vitamin B1.

Related Catalog

Signaling Pathways >> Others >> Others

Natural Products >> Alkaloid

Research Areas >> Neurological Disease

Solvent

In Vitro:

DMSO : ≥ 50 mg/mL (107.19 mM)

H₂O : 0.67 mg/mL (1.44 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

In Vivo: 1.Add each solvent one by one:  10% DMSO    90% corn oil Solubility: ≥ 2.5 mg/mL (5.36 mM); Clear solution 2.Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline) Solubility: ≥ 2.5 mg/mL (5.36 mM); Clear solution 3.Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline Solubility: ≥ 2.5 mg/mL (5.36 mM); Clear solution

Solubility

1 mM	2.1439 mL	10.7193 mL	21.4385 mL
5 mM	0.4288 mL	2.1439 mL	4.2877 mL
10 mM	0.2144 mL	1.0719 mL	2.1439 mL

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Shipping

Room temperature in continental US; may vary elsewhere